PREMIS Requirement Statement Project Report

This is the report of the PRESTA Project, the objective of which was to develop a requirements specification for preservation metadata based on the PREMIS (PREservation Metadata: Implementation Strategies) final report, the Data Dictionary for Preservation Metadata

Progress on optimizing miscanthus biomass production for the European bioeconomy:Results of the EU FP7 project OPTIMISC

This paper describes the complete findings of the EU-funded research project OPTIMISC, which investigated methods to optimize the production and use of miscanthus biomass. Miscanthus bioenergy and bioproduct chains were investigated by trialing 15 diverse germplasm types in a range of climatic and soil environments across central Europe, Ukraine, Russia, and China. The abiotic stress tolerances of a wider panel of 100 germplasm types to drought, salinity, and low temperatures were measured in the laboratory and a field trial in Belgium. A small selection of germplasm types was evaluated for performance in grasslands on marginal sites in Germany and the UK. The growth traits underlying biomass yield and quality were measured to improve regional estimates of feedstock availability. Several potential high-value bioproducts were identified. The combined results provide recommendations to policymakers, growers and industry. The major technical advances in miscanthus production achieved by OPTIMISC include: (1) demonstration that novel hybrids can out-yield the standard commercially grown genotype Miscanthus x giganteus; (2) characterization of the interactions of physiological growth responses with environmental variation within and between sites; (3) quantification of biomass-quality-relevant traits; (4) abiotic stress tolerances of miscanthus genotypes; (5) selections suitable for production on marginal land; (6) field establishment methods for seeds using plugs; (7) evaluation of harvesting methods; and (8) quantification of energy used in densification (pellet) technologies with a range of hybrids with differences in stem wall properties. End-user needs were addressed by demonstrating the potential of optimizing miscanthus biomass composition for the production of ethanol and biogas as well as for combustion. The costs and life-cycle assessment of seven miscanthusbased value chains, including small- and large-scale heat and power, ethanol, biogas, and insulation material production, revealed GHG-emission- and fossil-energy-saving potentials of up to 30.6 t CO2eqC ha(-1) y(-1) and 429 GJ ha(-1)y(-1), respectively. Transport distance was identified as an important cost factor. Negative carbon mitigation costs of-78 epsilon t(-1) CO2eq C were recorded for local biomass use. The OPTIMISC results demonstrate the potential of miscanthus as a crop for marginal sites and provide information and technologies for the commercial implementation of miscanthus-based value chains

Activation of epidermal growth factor receptor is required for Chlamydia trachomatis development

Background Chlamydia trachomatis (C. trachomatis) is a clinically significant human pathogen and one of the leading causative agents of sexually transmitted diseases. As obligate intracellular bacteria, C. trachomatis has evolved strategies to redirect the host’s signaling and resources for its own survival and propagation. Despite the clinical notoriety of Chlamydia infections, the molecular interactions between C. trachomatis and its host cell proteins remain elusive. Results In this study, we focused on the involvement of the host cell epidermal growth factor receptor (EGFR) in C. trachomatis attachment and development. A combination of molecular approaches, pharmacological agents and cell lines were used to demonstrate distinct functional requirements of EGFR in C. trachomatisinfection. We show that C. trachomatis increases the phosphorylation of EGFR and of its downstream effectors PLCγ1, Akt and STAT5. While both EGFR and platelet-derived growth factor receptor-β (PDGFRβ) are partially involved in bacterial attachment to the host cell surface, it is only the knockdown of EGFR and not PDGFRβ that affects the formation of C. trachomatis inclusions in the host cells. Inhibition of EGFR results in small immature inclusions, and prevents C. trachomatis-induced intracellular calcium mobilization and the assembly of the characteristic F-actin ring at the inclusion periphery. By using complementary approaches, we demonstrate that the coordinated regulation of both calcium mobilization and F-actin assembly by EGFR are necessary for maturation of chlamydial inclusion within the host cells. A particularly important finding of this study is the co-localization of EGFR with the F-actin at the periphery of C. trachomatis inclusion where it may function to nucleate the assembly of signaling protein complexes for cytoskeletal remodeling required for C. trachomatisdevelopment. Conclusion Cumulatively, the data reported here connect the function of EGFR to C. trachomatis attachment and development in the host cells, and this could lead to new venues for targeting C. trachomatis infections and associated diseases

The 2023 wearable photoplethysmography roadmap

Photoplethysmography is a key sensing technology which is used in wearable devices such as smartwatches and fitness trackers. Currently, photoplethysmography sensors are used to monitor physiological parameters including heart rate and heart rhythm, and to track activities like sleep and exercise. Yet, wearable photoplethysmography has potential to provide much more information on health and wellbeing, which could inform clinical decision making. This Roadmap outlines directions for research and development to realise the full potential of wearable photoplethysmography. Experts discuss key topics within the areas of sensor design, signal processing, clinical applications, and research directions. Their perspectives provide valuable guidance to researchers developing wearable photoplethysmography technology

CD4陽性T細胞に発現するA20(tnfaip3) はTh2型アレルギー性気道炎症を抑制する

研究科: 千葉大学大学院医学薬学府（先端医学薬学専攻）学位記番号: 千大院医薬博甲第医1412号博士（医学）千葉大学 = Chiba Universit

Trust and the Web: Can the Audit Checklist be Applied to Web Archives?

An increasing number of National Libraries and similar institutions are building Web archives: collections of materials representing their national or cultural documentary heritage as it is expressed in the online environment. The practice of Web archiving usually involves a harvest model, rather than a deposit model, and poses a number of documentation and validation issues that impact on a Web archive's ability to comply with the RLG/NARA audit checklist for Trusted Digital Repositories. This presentation explores some of these issues and proposes some ways in which the checklist may be applied in the Web archiving context

Safe Havens in a Choppy Sea: Digital Object Management Workflows at the National Library of Australia: Presentation - iPRES 2005 - Göttingen

The National Library of Australia collects, archives and provides access to a wide range of digital materials, including items from its image, map, manuscript and audio digitisation programmes, as well as significant Australian online resources harvested from the Web. The Library seeks to provide a safe place for the storage, management, preservation and delivery of its digital collections and has developed a layered digital services architecture to support these aims. This paper provides an overview of the Library's digital services architecture and the systems used to manage its main digital collections. It describes the design of the "Digital Collections Manager" and details the ingest and management workflows for archiving image and sound materials, including assignment of persistent identifiers and recording of object relationships, process histories and technical metadata. An overview of PANDAS, the Library's Web archiving and management system for PANDORA, Australia's Web Archive, is also provided.Die Nationalbibliothek von Australien sammelt, archiviert und bietet Zugang zu einer großen Auswahl an digitalem Material. Dies beinhaltet vielfältige digitalisierte Objekte (Bilder, Karten, Manuskripte und Audiomaterial) sowie signifikante australische Online-Ressourcen, die mittels Harvesting-Technologie aus dem Internet gesammelt werden. Die Bibliothek ist bestrebt, einen sicheren Ort für die Aufbewahrung, das Management, die Langzeitarchivierung und die Bereitstellung ihrer digitalen Sammlungen zu bieten und hat daher eine vielschichtige digitale Servicearchitektur entwickelt, um diesem Anspruch gerecht zu werden. Dieser Vortrag bietet einen überblick über diese digitale Servicearchitektur der Bibliothek und stellt die Systeme und Programme vor, die zum Management der großen digitalen Sammlungen genutzt werden. Die Präsentation erläutert das System/Programm "Digital Collections Manager " und beschreibt detailliert die einzelnen Arbeitsschritte hinsichtlich der Einspeisung und Verwaltung von archiviertem Bild- und Tonmaterial. Dazu gehört auch die Zuweisung von "Persistent Identifiers", die Abbildung von Beziehungen zwischen den Objekten, die Dokumentation der Historie von Prozessen und der technischen Metadaten. Abschließend wird PANDAS vorgestellt; ein System der Nationalbibliothek zur Archivierung und zum Management von Web-Ressourcen für PANDORA, das Australische Web-Archiv

Preservation Metadata: Adapting or Adopting PREMIS for APSR

Preservation metadata requirements for repositories: a project of the Australian Partnership for Sustainable Repositories (APSR) -- APSR aims to establish a centre of excellence in sustainable digital resource management and partner universities are developing demonstrator repositories built on sustainability principles. This paper presents the work of a project commissioned by APSR to specify requirements for the collection of metadata needed for long term continuity of access to digital collections. The project was called PRESTA (PREMIS Requirements Statement) but it took a broader view than PREMIS alone. The MetaArchive of Southern Digital Culture will discuss the first two years of deliverables (2004-2006) for their three year partnership for establishing a collaborative digital preservation network for southern cultural heritage materials

Preservation Metadata: Adapting or Adopting PREMIS for APSR: Presentation - iPRES 2006 - Ithaca

Preservation metadata requirements for repositories: a project of the Australian Partnership for Sustainable Repositories (APSR) -- APSR aims to establish a centre of excellence in sustainable digital resource management and partner universities are developing demonstrator repositories built on sustainability principles. This paper presents the work of a project commissioned by APSR to specify requirements for the collection of metadata needed for long term continuity of access to digital collections. The project was called PRESTA (PREMIS Requirements Statement) but it took a broader view than PREMIS alone. The MetaArchive of Southern Digital Culture will discuss the first two years of deliverables (2004-2006) for their three year partnership for establishing a collaborative digital preservation network for southern cultural heritage materials